Shirley MacLaine and Anthony Hopkins 

The movie was called A Change of Seasons, which was made in the year 1980, and both Hopkins and MacLaine were not the best of friends whilst it was being made. Hopkins just hated his co-star and he detested working with her. The problem was enough to disrupt the on screen chemistry between the two actors during the movie. Naturally, the movie did not do well at the box office and subsequently also at the critics’ notebook. So there you go, these are some of the famous off-screen argy-bargies between two lead actors of a movie. However, there might be a few more that are unknown to us, till date.